Gene_name | Experimentally Verified Resistance Gene Information | Predicted Resistance Gene Information |
cmtR | BacMet ID: BAC0071Code for:
RegulatorFamily: Contains 1 HTH arsR-type DNA-binding domain.Sequence: FASTACross-database IDs: LinkOrganism: Mycobacterium tuberculosisLocation:
ChromosomeCompound: Cobalt (Co), Nickel (Ni)Description: Metal-responsive transcriptional repressor for the cmt operon. Binding of cadmium or lead causes the repressor to dissociate from the DNA.Length (amino acid):
118Reference: Cavet et al. 2003; Pubmed- 12939264
| Similar
resistance genes in 'BacMet Predicted database' |
cnrA | BacMet ID: BAC0203Code for:
EffluxFamily: RND superfamily, AcrB/AcrD/AcrF familySequence: FASTACross-database IDs: LinkOrganism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)Location:
Plasmid pMOL28 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839))Compound: Cobalt (Co), Nickel (Ni)Description: Nickel and cobalt resistance protein CnrA. The products of the genes cnrA, cnrB, and cnrC are likely to form a membrane-bound protein complex catalyzing an energy-dependent efflux of Ni2+ and Co2+. The mechanism of action of the CnrCBA complex may be that of a proton/cation antiporter.Length (amino acid):
1076Reference: Liesegang et al. 1993; Pubmed- 8380802, Grass et al. 2000; Pubmed- 10671463
| Similar
resistance genes in 'BacMet Predicted database' |
cnrA | BacMet ID: BAC0542Code for:
EffluxFamily: RND superfamilySequence: FASTACross-database IDs: LinkOrganism: Bradyrhizobium sp. STM 2465Location:
ChromosomeCompound: Cobalt (Co), Nickel (Ni)Description: Fragment of nccA-like proteinLength (amino acid):
304Reference: Chaintreuil et al. 2007; Pubmed- 17951443
| Similar
resistance genes in 'BacMet Predicted database' |
cnrA | BacMet ID: BAC0543Code for:
EffluxFamily: RND superfamilySequence: FASTACross-database IDs: LinkOrganism: Bradyrhizobium sp. STM 2464Location:
ChromosomeCompound: Cobalt (Co), Nickel (Ni)Description: Fragment of nccA-like proteinLength (amino acid):
304Reference: Chaintreuil et al. 2007; Pubmed- 17951443
| Similar
resistance genes in 'BacMet Predicted database' |
cnrA | BacMet ID: BAC0544Code for:
EffluxFamily: RND superfamilySequence: FASTACross-database IDs: LinkOrganism: Bradyrhizobium sp. STM 2457Location:
ChromosomeCompound: Cobalt (Co), Nickel (Ni)Description: Fragment of nccA-like proteinLength (amino acid):
304Reference: Chaintreuil et al. 2007; Pubmed- 17951443
| Similar
resistance genes in 'BacMet Predicted database' |
cnrA | BacMet ID: BAC0545Code for:
EffluxFamily: RND superfamilySequence: FASTACross-database IDs: LinkOrganism: Bradyrhizobium sp. STM 2460Location:
ChromosomeCompound: Cobalt (Co), Nickel (Ni)Description: Fragment of nccA-like proteinLength (amino acid):
304Reference: Chaintreuil et al. 2007; Pubmed- 17951443
| Similar
resistance genes in 'BacMet Predicted database' |
cnrA | BacMet ID: BAC0546Code for:
EffluxFamily: RND superfamilySequence: FASTACross-database IDs: LinkOrganism: Bradyrhizobium sp. STM 2458Location:
ChromosomeCompound: Cobalt (Co), Nickel (Ni)Description: Fragment of nccA-like proteinLength (amino acid):
304Reference: Chaintreuil et al. 2007; Pubmed- 17951443
| Similar
resistance genes in 'BacMet Predicted database' |
cnrB | BacMet ID: BAC0204Code for:
EffluxFamily: Membrane Fusion Protein (MFP) familySequence: FASTACross-database IDs: LinkOrganism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)Location:
Plasmid pMOL28 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839))Compound: Cobalt (Co), Nickel (Ni)Description: Nickel and cobalt resistance protein CnrB. The products of the genes cnrA, cnrB, and cnrC are likely to form a membrane-bound protein complex catalyzing an energy-dependent efflux of Ni2+ and Co2+. The mechanism of action of the CnrCBA complex may be that of a proton/cation antiporter.Length (amino acid):
395Reference: Liesegang et al. 1993; Pubmed- 8380802, Grass et al. 2000; Pubmed- 10671463
| Similar
resistance genes in 'BacMet Predicted database' |
cnrC | BacMet ID: BAC0072Code for:
EffluxFamily: RND Superfamily, OMP familySequence: FASTACross-database IDs: LinkOrganism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)Location:
Plasmid pMOL28 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839))Compound: Cobalt (Co), Nickel (Ni)Description: Nickel and cobalt resistance protein CnrC; The products of the genes cnrA, cnrB, and cnrC are likely to form a membrane-bound protein complex catalyzing an energy-dependent efflux of Ni2+ and Co2+. The mechanism of action of the CnrCBA complex may be that of a proton/cation antiporter.Length (amino acid):
418Reference: Liesegang et al. 1993; Pubmed- 8380802, Grass et al. 2000; Pubmed- 10671463
| Similar
resistance genes in 'BacMet Predicted database' |
cnrH | BacMet ID: BAC0073Code for:
RegulatorFamily: Sigma-70 factor familySequence: FASTACross-database IDs: LinkOrganism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)Location:
Plasmid pMOL28 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839))Compound: Cobalt (Co), Nickel (Ni)Description: RNA polymerase sigma factor CnrH; CnrH alone is able to activate cnr Expression, and both CnrY and CrnX are needed for nickel induction of CnrH. In the absence of wild-type CnrY (due either to a frameshift or absence of the transcript, nickel and cobalt resistance is constitutive, indicating that CrnY may act as a repressor or an anti-sigma factor.Length (amino acid):
191Reference: Liesegang et al. 1993; Pubmed- 8380802, Grass et al. 2000; Pubmed- 10671463
| Similar
resistance genes in 'BacMet Predicted database' |
cnrR/cnrX | BacMet ID: BAC0291Code for:
RegulatorFamily: UnknownSequence: FASTACross-database IDs: LinkOrganism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)Location:
Plasmid pMOL28 (Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839))Compound: Cobalt (Co), Nickel (Ni)Description: Nickel and cobalt resistance operon regulator CnrR. CnrH alone is able to activate cnr expression, while both CnrY and CnrR (CnrX) are needed for nickel induction of CnrH. Has been suggested to bind nickel.Length (amino acid):
148Reference: Liesegang et al. 1993; Pubmed- 8380802, Grass et al. 2000; Pubmed- 10671463, Tibazarwa et al. 2000; Pubmed- 10671464
| Similar
resistance genes in 'BacMet Predicted database' |
cnrT | BacMet ID: BAC0074Code for:
Membrane TransporterFamily: EamA-like transporter familySequence: FASTACross-database IDs: LinkOrganism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)Location:
Plasmid pMOL28 (Cupriavidus metallidurans)Compound: Cobalt (Co), Nickel (Ni)Description: CnrT, Cation Diffusion Facilitator, involved in Co(II), Ni(II) resistanceLength (amino acid):
351Reference: Grass et al. 2000; Pubmed- 10671463
| Similar
resistance genes in 'BacMet Predicted database' |
cnrY | BacMet ID: BAC0075Code for:
RegulatorFamily: UnknownSequence: FASTACross-database IDs: LinkOrganism: Ralstonia metallidurans (strain CH34/ATCC 43123/DSM 2839)Location:
Plasmid pMOL28 (Cupriavidus metallidurans)Compound: Cobalt (Co), Nickel (Ni)Description: Nickel and cobalt resistance protein CnrY; CnrY and CnrX are needed for nickel induction of CnrH. In the absence of wild-type CnrY (due either to a frameshift) or absence of the transcript, nickel and cobalt resistance is constitutive, indicating that CrnY may act as a repressor or an anti-sigma factor.Length (amino acid):
95Reference: Liesegang et al. 1993; Pubmed- 8380802, Grass et al. 2000; Pubmed- 10671463
| Similar
resistance genes in 'BacMet Predicted database' |
corA | BacMet ID: BAC0086Code for:
Membrane TransporterFamily: CorA metal ion transporter (MIT) familySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Magnesium (Mg), Cobalt (Co), Nickel (Ni), Manganese (Mn)Description: Mediates influx of magnesium ions. Can also mediate cobalt and manganese uptake, albeit only at extracellular concentrations that are toxic to the cell. Does not transport iron.Length (amino acid):
316Reference: Park et al. 1976; Pubmed- 780341
| Similar
resistance genes in 'BacMet Predicted database' |
corA | BacMet ID: BAC0641Code for:
Membrane TransporterFamily: CorA metal ion transporter (MIT) familySequence: FASTACross-database IDs: LinkOrganism: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)Location:
ChromosomeCompound: Magnesium (Mg), Cobalt (Co), Nickel (Ni), Manganese (Mn)Description: Mediates both influx and efflux of magnesium ions. Can also mediate cobalt and nickel uptake, albeit only at extracellular concentrations that are toxic to the cell. Does not transport iron.Length (amino acid):
316Reference: Smith et al. 1998; Pubmed- 9786860, Gibson et al. 1991; Pubmed- 1779764, Hmiel et al. 1989; Pubmed- 2548998
| Similar
resistance genes in 'BacMet Predicted database' |
ctpD | BacMet ID: BAC0099Code for:
EnzymeFamily: Cation transport ATPase (P-type)family. Type IB subfamilySequence: FASTACross-database IDs: LinkOrganism: Mycobacterium smegmatisLocation:
ChromosomeCompound: Cobalt (Co), Nickel (Ni)Description: Probable cobalt/nickel-exporting P-type ATPase; Involved in heavy metal homeostasis. Probably exports nickel and cobalt ions out of the cell.Length (amino acid):
657Reference: Raimunda et al. 2012; Pubmed- 22591178
| Similar
resistance genes in 'BacMet Predicted database' |
cznA | BacMet ID: BAC0127Code for:
EffluxFamily: RND superfamily, AcrB/AcrD/AcrF familySequence: FASTACross-database IDs: LinkOrganism: Helicobacter mustelae (strain ATCC 43772/LMG 18044/NCTC 12198/12198)(Campylobacter mustelae)Location:
ChromosomeCompound: Cadmium (Cd), Zinc (Zn), Nickel (Ni)Description: Cadmium-zinc-nickel resistance protein cznALength (amino acid):
1019Reference: Stahler et al. 2006; Pubmed- 16790756
| Similar
resistance genes in 'BacMet Predicted database' |
cznB | BacMet ID: BAC0128Code for:
EffluxFamily: RND superfamily, MFP familySequence: FASTACross-database IDs: LinkOrganism: Helicobacter mustelae (strain ATCC 43772/LMG 18044/NCTC 12198/12198)(Campylobacter mustelae)Location:
ChromosomeCompound: Cadmium (Cd), Zinc (Zn), Nickel (Ni)Description: Cadmium-zinc-nickel resistance protein cznBLength (amino acid):
351Reference: Stahler et al. 2006; Pubmed- 16790756
| Similar
resistance genes in 'BacMet Predicted database' |
cznC | BacMet ID: BAC0129Code for:
EffluxFamily: RND Superfamily, OMP familySequence: FASTACross-database IDs: LinkOrganism: Helicobacter mustelae (strain ATCC 43772/LMG 18044/NCTC 12198/12198) (Campylobacter mustelae)Location:
ChromosomeCompound: Cadmium (Cd), Zinc (Zn), Nickel (Ni)Description: Cadmium-zinc-nickel outer membrane efflux protein cznCLength (amino acid):
424Reference: Stahler et al. 2006; Pubmed- 16790756
| Similar
resistance genes in 'BacMet Predicted database' |
dmeF | BacMet ID: BAC0132Code for:
EffluxFamily: Cation diffusion facilitator (CDF) transporter familySequence: FASTACross-database IDs: LinkOrganism: Wautersia metallidurans CH34Location:
Plasmid pMOL28 (Wautersia metallidurans CH34)Compound: Cobalt (Co), Cadmium (Cd), Nickel (Ni)Description: DmeF is a broad-range metal ion transporter that functions in E. coli and W. metallidurans. dmeF plays the central role in cobalt homeostasis in Wautersia metallidurans CH34.Length (amino acid):
382Reference: Scherer et al. 2009; Pubmed- 19602147, Munkelt et al. 2004; Pubmed- 15547276
| Similar
resistance genes in 'BacMet Predicted database' |
dmeF | BacMet ID: BAC0482Code for:
EffluxFamily: Cation Diffusion Facilitator (CDF) familySequence: FASTACross-database IDs: LinkOrganism: Rhizobium leguminosarum bv. viciae UPM791Location:
ChromosomeCompound: Cobalt (Co), Nickel (Ni)Description: Member of the dmeRF efflux system which is a metal responsive efflux system acts as a key element for metal homeostasis in Rhizobium leguminosarum under free-living and symbiotic conditions. Length (amino acid):
323Reference: Rubio-Sanz et al. 2013; Pubmed- 23934501
| Similar
resistance genes in 'BacMet Predicted database' |
dmeR | BacMet ID: BAC0475Code for:
EffluxFamily: Cation Diffusion Facilitator (CDF) familySequence: FASTACross-database IDs: LinkOrganism: Rhizobium leguminosarum bv. viciae UPM791Location:
ChromosomeCompound: Cobalt (Co), Nickel (Ni)Description: Member of the dmeRF efflux system which is a metal responsive efflux system acts as a key element for metal homeostasis in Rhizobium leguminosarum under free-living and symbiotic conditions. Length (amino acid):
90Reference: Rubio-Sanz et al. 2013; Pubmed- 23934501
| Similar
resistance genes in 'BacMet Predicted database' |
fecD | BacMet ID: BAC0163Code for:
EnzymeFamily: Binding-protein-dependent transport system permease family. FecCD subfamilySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Nickel (Ni), Cobalt (Co)Description: Fe(3+) dicitrate transport system permease protein FecD; Part of the binding-protein-dependent transport system for citrate-dependent Fe3+. Probably responsible for the translocation of the substrate across the membrane.Length (amino acid):
318Reference: Stoof et al. 2010; Pubmed- 20643857
| Similar
resistance genes in 'BacMet Predicted database' |
fecE | BacMet ID: BAC0164Code for:
Membrane TransporterFamily: ABC transporter superfamilySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Nickel (Ni), Cobalt (Co)Description: Fe(3+) dicitrate transport ATP-binding protein FecE; Part of the binding-protein-dependent transport system for citrate-dependent Fe3+. Probably responsible for energy coupling to the transport systemLength (amino acid):
255Reference: Stoof et al. 2010; Pubmed- 20643857
| Similar
resistance genes in 'BacMet Predicted database' |
fieF/yiip | BacMet ID: BAC0167Code for:
EffluxFamily: Cation diffusion facilitator (CDF) transporter familySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Iron (Fe), Zinc (Zn), Cobalt (Co), Cadmium (Cd), Nickel (Ni)Description: Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn2+ in a proton-dependent manner. The CDF protein, FieF, is mainly a ferrous iron detoxifying protein but also mediated some resistance against other divalent metal cations such as Zn(II), Co(II), Cd(II), and Ni(II) in W. metallidurans or Escherichia coli.Length (amino acid):
300Reference: Grass et al. 2005; Pubmed- 15549269, Munkelt et al. 2004; Pubmed- 15547276
| Similar
resistance genes in 'BacMet Predicted database' |
fptA | BacMet ID: BAC0168Code for:
PorinFamily: General Bacterial Porin family (GBP) superfamily. TonB-dependent receptor familySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)Location:
ChromosomeCompound: Iron (Fe), Cobalt (Co), Nickel (Ni), Gallium (Ga)Description: Fe(3+)-pyochelin receptor FptA; High-affinity outer membrane receptor required for the transport of Fe3+-pyochelinLength (amino acid):
720Reference: Braud et al. 2009; Pubmed- 19329644
| Similar
resistance genes in 'BacMet Predicted database' |
fpvA | BacMet ID: BAC0169Code for:
PorinFamily: General Bacterial Porin family (GBP) superfamily. TonB-dependent receptor familySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)Location:
ChromosomeCompound: Manganese (Mn), Iron (Fe), Cobalt (Co), Zinc (Zn), Nickel (Ni), Copper (Cu), Cadmium (Cd), Gallium (Ga)Description: Ferripyoverdine receptor A (fpvA); Receptor for the siderophore ferripyoverdine; Located in cell outer membraneLength (amino acid):
815Reference: Hannauer et al. 2012; Pubmed- 22187978, Braud et al. 2009; Pubmed- 19207567
| Similar
resistance genes in 'BacMet Predicted database' |
hoxN | BacMet ID: BAC0191Code for:
EnzymeFamily: NiCo transporter familySequence: FASTACross-database IDs: LinkOrganism: Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)Location:
Plasmid megaplasmid pHG1 (Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha)),Compound: Nickel (Ni)Description: High-affinity nickel transporter hoxN responsible for nickel uptake. Necessary for high levels of activity of hydrogenase and urease.Length (amino acid):
351Reference: Eitinger et al. 1991; Pubmed- 1847142, Wolfram et al. 1995; Pubmed- 7896709
| Similar
resistance genes in 'BacMet Predicted database' |
hupE | BacMet ID: BAC0483Code for:
EnzymeFamily: HupE/UreJ familySequence: FASTACross-database IDs: LinkOrganism: Rhizobium leguminosarum bv. ViciaeLocation:
Plasmid pSym (Rhizobium leguminosarum bv. viciae)Compound: Nickel (Ni)Description: It is a metal permease. hupE gene, part of a highly conserved hup cluster and evolutionarily related to hydrogenase genes. It has a potential role as a nickel permease. It encodes a nickel transporter required for hydrogenase activity. Length (amino acid):
191Reference: Brito et al. 2010; Pubmed- 20023036
| Similar
resistance genes in 'BacMet Predicted database' |
hupE2 | BacMet ID: BAC0484Code for:
EnzymeFamily: HupE/UreJ familySequence: FASTACross-database IDs: LinkOrganism: Rhizobium leguminosarum bv. viciae UPM791Location:
Plasmid pRLUPM791b (Rhizobium leguminosarum bv. viciae UPM791b)Compound: Nickel (Ni)Description: A hupE-homolog. It is a metal permease. There is a low level of amino acid sequence identity between hupE and hupE2. It is involved in hydrogen oxidation in R. leguminosarum bv. Viciae. Length (amino acid):
199Reference: Brito et al. 2010; Pubmed- 20023036
| Similar
resistance genes in 'BacMet Predicted database' |
hupN | BacMet ID: BAC0193Code for:
EnzymeFamily: HupF/HypC familySequence: FASTACross-database IDs: LinkOrganism: Azotobacter chroococcum mcd 1Location:
ChromosomeCompound: Nickel (Ni)Description: Hydrogenase nickel incorporation protein HupNLength (amino acid):
108Reference: Fu et al. 1994; Pubmed- 8197192
| Similar
resistance genes in 'BacMet Predicted database' |
kmtR | BacMet ID: BAC0201Code for:
RegulatorFamily: Contains 1 HTH arsR-type DNA-binding domainSequence: FASTACross-database IDs: LinkOrganism: Mycobacterium tuberculosisLocation:
ChromosomeCompound: Nickel (Ni), Cobalt (Co)Description: HTH-type transcriptional regulator KmtR; response to cobalt and nickel ions; Negatively auto-regulatedLength (amino acid):
130Reference: Campbell et al. 2007; Pubmed- 17726022
| Similar
resistance genes in 'BacMet Predicted database' |
mrdH | BacMet ID: BAC0254Code for:
Membrane TransporterFamily: NicO familySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas putida (strain KT2440)Location:
Plasmid pWW0 (Pseudomonas putida (Arthrobacter siderocapsulatus))Compound: Nickel (Ni), Cadmium (Cd), Zinc (Zn), Cobalt (Co)Description: Membrane protein transpoeter mrdHLength (amino acid):
377Reference: Haritha et al. 2009; Pubmed- 19648243
| Similar
resistance genes in 'BacMet Predicted database' |
mreA | BacMet ID: BAC0255Code for:
RegulatorFamily: ABC superfamilySequence: FASTACross-database IDs: LinkOrganism: Pseudomonas putida (strain KT2440)Location:
ChromosomeCompound: Nickel (Ni), Zinc (Zn)Description: Metal-sensitive repressor mreA, involved in resistance to metal ions. Bind nickel or zinc ions via conserved cysteine and histidine residues. In the absence of metal ions, this protein bind to promoter regions and repress transcriptionLength (amino acid):
95Reference: Haritha et al. 2009; Pubmed- 19648243
| Similar
resistance genes in 'BacMet Predicted database' |
mymT | BacMet ID: BAC0262Code for:
Binding proteinFamily: Metallothionein superfamilySequence: FASTACross-database IDs: LinkOrganism: Mycobacterium tuberculosisLocation:
ChromosomeCompound: Copper (Cu), Nickel (Ni), Zinc (Zn)Description: Cu(I)-binding metallothionein mymT; Metallothioneins are small proteins that have a high content of cysteine residues wich allow them to bind heavy metal ions through clusters of thiolate bonds. MymT binds up to seven ions of Cu+, with a preference for four to six Cu+ ions, in a solvent-shielded core. MymT protects M. tuberculosis from copper toxicity. Up-regulated by copper, cadmium, cobalt, nickel and zinc, but not manganese.Length (amino acid):
53Reference: Gold et al. 2011; Pubmed- 18724363, Festa et al. 2011; Pubmed- 21166899
| Similar
resistance genes in 'BacMet Predicted database' |
nccA | BacMet ID: BAC0549Code for:
EffluxFamily: RND superfamily, AcrB/AcrD/AcrF familySequence: FASTACross-database IDs: LinkOrganism: Alcaligenes xylosoxidans 31ALocation:
Plasmid pTOM9Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)Description: Nickel-cobalt-cadmium resistance protein NccA. Component of the NCC cation-efflux system (nccYXHCBAN) that confers resistance to nickel, cobalt and cadmium. May form a membrane tunnel, which allows ion transport across the membrane.Length (amino acid):
1076Reference: Schmidt et al. 1994; Pubmed- 7961470
| Similar
resistance genes in 'BacMet Predicted database' |
nccB | BacMet ID: BAC0550Code for:
EffluxFamily: RND superfamily, Membrane Fusion Protein (MFP) familySequence: FASTACross-database IDs: LinkOrganism: Alcaligenes xylosoxidans 31ALocation:
Plasmid pTOM9Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)Description: Nickel-cobalt-cadmium resistance protein NccB. Component of the NCC cation efflux system ((nccYXHCBAN)) that confers resistance to nickel, cobalt and cadmium. Length (amino acid):
397Reference: Schmidt et al. 1994; Pubmed- 7961470
| Similar
resistance genes in 'BacMet Predicted database' |
nccC | BacMet ID: BAC0551Code for:
EffluxFamily: RND superfamily, Outer Membrane factor (OMF) familySequence: FASTACross-database IDs: LinkOrganism: Alcaligenes xylosoxidans 31ALocation:
Plasmid pTOM9Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)Description: Nickel-cobalt-cadmium resistance protein NccC. Component of the NCC cation-efflux system (nccYXHCBAN)) that confers resistance to nickel, cobalt and cadmium.Length (amino acid):
437Reference: Schmidt et al. 1994; Pubmed- 7961470
| Similar
resistance genes in 'BacMet Predicted database' |
nccH | BacMet ID: BAC0555Code for:
RegulatorFamily: Sigma-70 factor family. ECF subfamilySequence: FASTACross-database IDs: LinkOrganism: Alcaligenes xylosoxidans 31ALocation:
Plasmid pTOM9Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)Description: RNA polymerase sigma factor NccH. Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor regulates the genes for a membrane-located efflux system ((nccYXHCBAN) that confers resistance to nickel, cobalt and cadmium.Length (amino acid):
186Reference: Schmidt et al. 1994; Pubmed- 7961470
| Similar
resistance genes in 'BacMet Predicted database' |
nccN | BacMet ID: BAC0554Code for:
Membrane TransporterFamily: Contains 1 Phospholipid methyltransferase domainSequence: FASTACross-database IDs: LinkOrganism: Alcaligenes xylosoxidans 31ALocation:
Plasmid pTOM9Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)Description: Nickel-cobalt-cadmium resistance protein NccN. Component of the NCC cation-efflux system (nccYXHCBAN) that confers resistance to nickel, cobalt and cadmium. Appears to be involved in metal specificity but affects only nickel resistance. May be involved in nickel transport.Length (amino acid):
213Reference: Schmidt et al. 1994; Pubmed- 7961470
| Similar
resistance genes in 'BacMet Predicted database' |
nccX | BacMet ID: BAC0553Code for:
RegulatorFamily: contains 1 heavy-metal resistance domainSequence: FASTACross-database IDs: LinkOrganism: Alcaligenes xylosoxidans 31ALocation:
Plasmid pTOM9Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)Description: Nickel-cobalt-cadmium resistance protein NccX. Component of the Ncc cation-efflux system ((nccYXHCBAN)) that confers resistance to nickel, cobalt and cadmium. May be involved in the regulation of Ncc.Length (amino acid):
148Reference: Schmidt et al. 1994; Pubmed- 7961470
| Similar
resistance genes in 'BacMet Predicted database' |
nccY | BacMet ID: BAC0552Code for:
RegulatorFamily: UnknownSequence: FASTACross-database IDs: LinkOrganism: Alcaligenes xylosoxidans 31ALocation:
Plasmid pTOM9Compound: Nickel (Ni), Cobalt (Co), Cadmium (Cd)Description: Nickel-cobalt-cadmium resistance protein NccY. Component of the Ncc cation-efflux system that confers resistance to nickel, cobalt and cadmium. May be involved in the regulation of Ncc.Length (amino acid):
95Reference: Schmidt et al. 1994; Pubmed- 7961470
| Similar
resistance genes in 'BacMet Predicted database' |
ncrA | BacMet ID: BAC0263Code for:
EffluxFamily: MFS superfamilySequence: FASTACross-database IDs: LinkOrganism: Leptospirillum ferriphilumLocation:
ChromosomeCompound: Nickel (Ni)Description: Chromosomal nickel-resistant determinant ncrA found both in chromosome and plasmids. Part of ncrABCY nickel resistance Chromosomal determinant system. It encodes a membrane protein that forms an efflux with another membrane protein ncrC.Length (amino acid):
432Reference: Tian et al. 2007; Pubmed- 17293508, Zhu et al. 2011; Pubmed- 21387010
| Similar
resistance genes in 'BacMet Predicted database' |
ncrA | BacMet ID: BAC0698Code for:
EffluxFamily: MFS superfamilySequence: FASTACross-database IDs: LinkOrganism: Serratia marcescens strain C-1Location:
ChromosomeCompound: Cobalt (Co), Nickel (Ni)Description: Part of the ncrABC determinant sytem. NcrA contributes to nickel and cobalt resistance in this bacterium.Length (amino acid):
432Reference: Marrero et al. 2007; Pubmed- 17186148
| Similar
resistance genes in 'BacMet Predicted database' |
ncrA | BacMet ID: BAC0702Code for:
EffluxFamily: MFS superfamilySequence: FASTACross-database IDs: LinkOrganism: Hafnia alvei 5-5Location:
Plasmid pNRS148Compound: Cobalt (Co), Nickel (Ni)Description: Plasmid-borne ncrA protein. It encodes a membrane protein that forms an efflux with another membrane protein ncrC. Part of ncrABCY nickel resistance determinant system.Length (amino acid):
277Reference: Park et al. 2004; Pubmed- 15179604
| Similar
resistance genes in 'BacMet Predicted database' |
ncrB | BacMet ID: BAC0264Code for:
RegulatorFamily: Transcriptional repressor metal familySequence: FASTACross-database IDs: LinkOrganism: Leptospirillum ferriphilumLocation:
ChromosomeCompound: Nickel (Ni)Description: Chromosomal nickel-resistant determinant ncrB which is cytoplasmic, histidine-rich protein found in both chromosome and plasmids; probabale metal-sensitive repressor, involved in resistance to nickel ionsLength (amino acid):
89Reference: Tian et al. 2007; Pubmed- 17293508, Zhu et al. 2011; Pubmed- 21387010
| Similar
resistance genes in 'BacMet Predicted database' |
ncrB | BacMet ID: BAC0699Code for:
RegulatorFamily: Transcriptional repressor metal familySequence: FASTACross-database IDs: LinkOrganism: Serratia marcescens strain C-1Location:
ChromosomeCompound: Cobalt (Co), Nickel (Ni)Description: Probabale metal-sensitive repressor, involved in resistance to nickel ions. Part of ncrABCY nickel resistance determinant system.Length (amino acid):
89Reference: Marrero et al. 2007; Pubmed- 17186148
| Similar
resistance genes in 'BacMet Predicted database' |
ncrB | BacMet ID: BAC0703Code for:
RegulatorFamily: Transcriptional repressor metal familySequence: FASTACross-database IDs: LinkOrganism: Hafnia alvei 5-5Location:
Plasmid pNRS148Compound: Cobalt (Co), Nickel (Ni)Description: Plasmid-borne ncrB protein. Probabale metal-sensitive repressor, involved in resistance to nickel ions. Part of ncrABCY nickel resistance determinant system.Length (amino acid):
301Reference: Park et al. 2004; Pubmed- 15179604
| Similar
resistance genes in 'BacMet Predicted database' |
ncrC | BacMet ID: BAC0265Code for:
EffluxFamily: NicOT familySequence: FASTACross-database IDs: LinkOrganism: Leptospirillum ferriphilumLocation:
ChromosomeCompound: Nickel (Ni)Description: Chromosomal nickel-resistant membrane protein NcrC found both in chromosome and plasmids. Part of ncrABCY nickel resistance determinant system. It encodes a membrane protein that forms an efflux with another membrane protein ncrA.Length (amino acid):
376Reference: Tian et al. 2007; Pubmed- 17293508, Zhu et al. 2011; Pubmed- 21387010
| Similar
resistance genes in 'BacMet Predicted database' |
ncrC | BacMet ID: BAC0700Code for:
EffluxFamily: Nickel-cobalt transport (NicOT) familySequence: FASTACross-database IDs: LinkOrganism: Serratia marcescens strain C-1Location:
ChromosomeCompound: Cobalt (Co), Nickel (Ni)Description: Part of ncrABCY nickel resistance determinant system. It encodes a membrane protein that forms an efflux with another membrane protein ncrA.Length (amino acid):
231Reference: Marrero et al. 2007; Pubmed- 17186148
| Similar
resistance genes in 'BacMet Predicted database' |
ncrC | BacMet ID: BAC0704Code for:
EffluxFamily: Nickel-cobalt transport (NicOT) familySequence: FASTACross-database IDs: LinkOrganism: Hafnia alvei 5-5Location:
Plasmid pNRS148Compound: Cobalt (Co), Nickel (Ni)Description: Plasmid-borne ncrC protein. Part of ncrABCY nickel resistance determinant system. It encodes a membrane protein that forms an efflux with another membrane protein ncrA.Length (amino acid):
152Reference: Park et al. 2004; Pubmed- 15179604
| Similar
resistance genes in 'BacMet Predicted database' |
ncrY | BacMet ID: BAC0266Code for:
RegulatorFamily: Bacterial OB fold (BOF) protein familySequence: FASTACross-database IDs: LinkOrganism: Leptospirillum ferriphilumLocation:
ChromosomeCompound: Nickel (Ni)Description: Chromosoaml nickel-resistant determinant ncrY found both in chromosome and plasmids; some claims it has a negative effect on nickel resistance.Length (amino acid):
140Reference: Tian et al. 2007; Pubmed- 17293508, Zhu et al. 2011; Pubmed- 21387010
| Similar
resistance genes in 'BacMet Predicted database' |
ncrY | BacMet ID: BAC0701Code for:
RegulatorFamily: Bacterial OB fold (BOF) protein familySequence: FASTACross-database IDs: LinkOrganism: Hafnia alvei 5-5Location:
Plasmid pNRS148Compound: Cobalt (Co), Nickel (Ni)Description: Plasmid-borne NcrY protein. Part of ncrABCY nickel resistance determinant system. Some claims it has a negative effect on nickel resistance.Length (amino acid):
63Reference: Park et al. 2004; Pubmed- 15179604
| Similar
resistance genes in 'BacMet Predicted database' |
nczA | BacMet ID: BAC0267Code for:
RegulatorFamily: RND superfamily, AcrB/AcrD/AcrF familySequence: FASTACross-database IDs: LinkOrganism: Caulobacter crescentus (strain NA1000 / CB15N)Location:
ChromosomeCompound: Nickel (Ni), Cobalt (Co), Zinc (Zn)Description: Nickel-cobalt-zinc resistance protein nczA; part of the nczCBA operon; The nczCBA operon is induced maximally by Ni2+ and Co2+, moderately by Zn2+ but not by Cd2+. NczCBA transports Ni2+ Co2+ and probably Zn2+Length (amino acid):
1057Reference: Valencia et al. 2013; Pubmed- 23578014
| Similar
resistance genes in 'BacMet Predicted database' |
nia | BacMet ID: BAC0269Code for:
EnzymeFamily: Cation transport ATPase (P-type) familySequence: FASTACross-database IDs: LinkOrganism: Sinorhizobium melitoliLocation:
Plasmid pSymA (Sinorhizobium melitoli)Compound: Iron (Fe), Nickel (Ni)Description: P1B-5-ATPase; Has role in detoxification of Fe (II)+ and Ni (II)+ under free living conditions as well as in symbiosis.Length (amino acid):
799Reference: Zielazinski et al. 2013; Pubmed- 24056637
| Similar
resistance genes in 'BacMet Predicted database' |
nikA | BacMet ID: BAC0270Code for:
Binding proteinFamily: Bacterial solute-binding protein 5 familySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Nickel (Ni)Description: Nickel-binding periplasmic protein nikA; Involved in a nickel transport system, represents the nickel binder. Part of the Nik operon (NikABCDE), Solute-binding proteinLength (amino acid):
524Reference: Wu et al. 1991; Pubmed- 1743519, De Pina et al. 1995; Pubmed- 7867647
| Similar
resistance genes in 'BacMet Predicted database' |
nikB | BacMet ID: BAC0271Code for:
Membrane TransporterFamily: Binding-protein-dependent transport system permease family. OppBC subfamilySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Nickel (Ni)Description: Nickel transport system permease protein NikB; Transmembrane protein; Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane. Part of the Nik operon (NikABCDE)Length (amino acid):
314Reference: Wu et al. 1991; Pubmed- 1743519, Navarro et al. 1993; Pubmed- 7934931
| Similar
resistance genes in 'BacMet Predicted database' |
nikC | BacMet ID: BAC0272Code for:
Membrane TransporterFamily: Binding-protein-dependent transport system permease family. OppBC subfamilySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Nickel (Ni)Description: Nickel transport system permease protein NikC; Transmembrane protein; Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane. Part of the Nik operon (NikABCDE)Length (amino acid):
277Reference: Navarro et al. 1993; Pubmed- 7934931
| Similar
resistance genes in 'BacMet Predicted database' |
nikD | BacMet ID: BAC0273Code for:
Binding proteinFamily: ABC transporter superfamily. Nickel importer familySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Nickel (Ni)Description: Nickel import ATP-binding protein NikD; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Part of the Nik operon (NikABCDE)Length (amino acid):
254Reference: Navarro et al. 1993; Pubmed- 7934931
| Similar
resistance genes in 'BacMet Predicted database' |
nikE | BacMet ID: BAC0274Code for:
Binding proteinFamily: ABC transporter superfamily. Nickel importer familySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Nickel (Ni)Description: Nickel import ATP-binding protein NikE; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system.Length (amino acid):
268Reference: Navarro et al. 1993; Pubmed- 7934931
| Similar
resistance genes in 'BacMet Predicted database' |
nikR | BacMet ID: BAC0275Code for:
RegulatorFamily: Transcriptional regulatory CopG/NikR familySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Nickel (Ni)Description: Nickel-responsive regulator nikR; Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel.Length (amino acid):
133Reference: De Pina et al. 1999; Pubmed- 9882686, Contreras et al. 2003; Pubmed- 12890020
| Similar
resistance genes in 'BacMet Predicted database' |
nirA | BacMet ID: BAC0276Code for:
Membrane TransporterFamily: MFS superfamilySequence: FASTACross-database IDs: LinkOrganism: Klebsiella oxytocaLocation:
ChromosomeCompound: Nickel (Ni)Description: Chromosomal nickel resistance determinant nirA. C-terminal of the nirA protien contains a histidine rich region tat might possess high affinity to nickel. Length (amino acid):
356Reference: Park et al. 2008; Pubmed- 18600044
| Similar
resistance genes in 'BacMet Predicted database' |
nirB | BacMet ID: BAC0277Code for:
RegulatorFamily: Transcriptional repressor metal familySequence: FASTACross-database IDs: LinkOrganism: Klebsiella oxytocaLocation:
ChromosomeCompound: Nickel (Ni)Description: Chromosomal nickel resistance determinant nirB. It has 98% amino acid sequence similarity to chromosomal ncrB.Length (amino acid):
89Reference: Park et al. 2008; Pubmed- 18600044
| Similar
resistance genes in 'BacMet Predicted database' |
nirC | BacMet ID: BAC0278Code for:
Membrane TransporterFamily: NicO transporter familySequence: FASTACross-database IDs: LinkOrganism: Klebsiella oxytocaLocation:
ChromosomeCompound: Nickel (Ni)Description: Chromosomal nickel resistance determinant nirC. It is a memebrane protein like ABC-type transport proteins and also possess a histidine rich region with high affinity for nickel binding.Length (amino acid):
307Reference: Park et al. 2008; Pubmed- 18600044
| Similar
resistance genes in 'BacMet Predicted database' |
nirD | BacMet ID: BAC0279Code for:
RegulatorFamily: Bacterial OB fold (BOF) protein familySequence: FASTACross-database IDs: LinkOrganism: Klebsiella oxytocaLocation:
ChromosomeCompound: Nickel (Ni)Description: Chromosomal nickel resistance determinant nirD; has 75% amino acid sequence similarity to chromomosomal ncrY.Length (amino acid):
164Reference: Park et al. 2008; Pubmed- 18600044
| Similar
resistance genes in 'BacMet Predicted database' |
nixA | BacMet ID: BAC0280Code for:
EnzymeFamily: NiCo transporter familySequence: FASTACross-database IDs: LinkOrganism: Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)Location:
Plasmid pRHL2 (Rhodococcus sp. (strain RHA1))Compound: Nickel (Ni)Description: High-affinity nickel intake protein nixA. Imports nickel ions in an energy-dependent fashion. Necessary for the Expression of catalytically active urease.Length (amino acid):
331Reference: Mobley et al. 1995; Pubmed- 7651142
| Similar
resistance genes in 'BacMet Predicted database' |
nmtR | BacMet ID: BAC0281Code for:
RegulatorFamily: ArsR-SmtB familySequence: FASTACross-database IDs: LinkOrganism: Mycobacterium tuberculosisLocation:
ChromosomeCompound: Nickel (Ni), Cadmium (Cd), Lead (Pb)Description: Represses transcription of ctpJ/nmtA, by binding to its promoter regionLength (amino acid):
120Reference: Cavet et al. 2002; Pubmed- 12163508
| Similar
resistance genes in 'BacMet Predicted database' |
nreB | BacMet ID: BAC0285Code for:
EnzymeFamily: MFS superfamilySequence: FASTACross-database IDs: LinkOrganism: Acromobacter xylosoxidans 31A, Synechocystis spp.Location:
Plasmid pMOL30 (Ralstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)),Compound: Cobalt (Co), Nickel (Ni)Description: Nickel resistance protein nreB (also known as nrsD or entS); nickel permease involved in nickel and cobalt tolerance. The histidine-rich C-terminal region of the nreB is not essential but contributes to maximal Ni(II) resistance. Length (amino acid):
416Reference: Grass et al. 2001; Pubmed- 11292799
| Similar
resistance genes in 'BacMet Predicted database' |
nrsA | BacMet ID: BAC0286Code for:
Membrane TransporterFamily: RND superfamily, AcrB/AcrD/AcrF familySequence: FASTACross-database IDs: LinkOrganism: Synechocystis sp. (strain PCC 6803 / Kazusa)Location:
ChromosomeCompound: Nickel (Ni)Description: Cation or drug efflux system protein nrsALength (amino acid):
1054Reference: Garcia-Dominquez et al. 2000; Pubmed- 10692354
| Similar
resistance genes in 'BacMet Predicted database' |
nrsD/nreB | BacMet ID: BAC0287Code for:
EnzymeFamily: MFS superfamilySequence: FASTACross-database IDs: LinkOrganism: Acinetobacter calcoaceticus (strain PHEA-2), Synechocystis sp. (strain PCC 6803 / Kazusa)Location:
ChromosomeCompound: Nickel (Ni), Cobalt (Co)Description: nrsD gene encodes a Ni(II) permease whose carboxy-terminal region is a metal binding domain; nickel permease involved in nickel and cobalt toleranceLength (amino acid):
445Reference: Garcia-Dominquez et al. 2000; Pubmed- 10692354
| Similar
resistance genes in 'BacMet Predicted database' |
nrsR | BacMet ID: BAC0288Code for:
RegulatorFamily: Contains 1 response regulatory domainSequence: FASTACross-database IDs: LinkOrganism: Synechocystis sp. (strain PCC 6803 / GT-S)Location:
ChromosomeCompound: Nickel (Ni)Description: OmpR subfamily protein NrsR/RppA/Rre33Length (amino acid):
234Reference: Lopez-Maury et al. 2002; Pubmed- 11849552
| Similar
resistance genes in 'BacMet Predicted database' |
nrsS | BacMet ID: BAC0289Code for:
EnzymeFamily: Contains 1 histidine kinase domainSequence: FASTACross-database IDs: LinkOrganism: Synechocystis sp. (strain PCC 6803 / GT-S)Location:
ChromosomeCompound: Nickel (Ni)Description: Sensory transduction histidine kinase NrsS/RppB/Hik30Length (amino acid):
454Reference: Lopez-Maury et al. 2002; Pubmed- 11849552
| Similar
resistance genes in 'BacMet Predicted database' |
rcnA/yohM | BacMet ID: BAC0330Code for:
EffluxFamily: NicO transporter familySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Cobalt (Co), Nickel (Ni), Iron (Fe)Description: Efflux system rcnA for nickel and cobalt; Transcriptionally repressed by RcnR. Probably also regulated by Fur. Cadmium, copper and zinc have no effect on the transcriptionLength (amino acid):
274Reference: Rodrigue et al. 2005; Pubmed- 15805538, Koch et al. 2007; Pubmed- 17120142
| Similar
resistance genes in 'BacMet Predicted database' |
rcnB/yohN | BacMet ID: BAC0331Code for:
EffluxFamily: RcnB familySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Nickel (Ni), Cobalt (Co)Description: Nickel/cobalt homeostasis protein RcnB; Act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly. Repressed by RcnR. Induced by nickel and cobaltLength (amino acid):
112Reference: Bleriot et al. 2011; Pubmed- 21665978
| Similar
resistance genes in 'BacMet Predicted database' |
rcnR/yohL | BacMet ID: BAC0332Code for:
RegulatorFamily: FrmR/RcnR familySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Cobalt (Co), Nickel (Ni), Iron (Fe)Description: Repressor of rcnA, rcnR. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter. Can repress the rcnB expression as well.Length (amino acid):
90Reference: Koch et al. 2007; Pubmed- 17120142
| Similar
resistance genes in 'BacMet Predicted database' |
yqjH | BacMet ID: BAC0452Code for:
EnzymeFamily: SIP oxidoreductase familySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Iron (Fe), Nickel (Ni)Description: NADPH-dependent ferric-chelate reductase (Ferric siderophore reductase) YqjH; Plays a role in iron homeostasis under excess nickel conditions; Repressed by YqjI and Fur. YqjI is required for nickel-dependent regulation of yqjH, while Fur is required for iron- and cobalt-dependent regulation of yqjhLength (amino acid):
254Reference: Wang et al. 2011; Pubmed- 21097627
| Similar
resistance genes in 'BacMet Predicted database' |
zupT/ygiE | BacMet ID: BAC0469Code for:
PorterFamily: ZIP transporter family, ZupT subfamilySequence: FASTACross-database IDs: LinkOrganism: Escherichia coli (strain K12)Location:
ChromosomeCompound: Zinc (Zn), Iron (Fe), Cobalt (Co), Nickel (Ni), Copper (Cu), Cadmium (Cd)Description: Zinc transporter ZupT; Mediates zinc uptake. May also transport other divalent cations such as copper and cadmium ions.Length (amino acid):
257Reference: Grass et al. 2005; Pubmed- 15716430
| Similar
resistance genes in 'BacMet Predicted database' |